Servings Per Container: 60 vegetarian capsules 500 mg. each

Ingredients: Per Serving (one capusle) - Forslean (Choleus Forskoli) 20% extract 125mg , Citrin 50% extract 350mg., Gymnemna Sylvestre 75% extract 10mg., Guggul extract 10mg., Bioperine 98% extract 5mg.

Recommended Dosage : 1 capsule twice a day 30 minutes before meals

Indications:

Lean Plus combines the properties of Forslean (Choleus Forskoli) to help convert fat to lean body mass and Citrin which helps to control the appetite in one powerful capsule. Lean Plus delivers the recommended dosage of Forslean (50mg. per day) in two vegetarian capsules. Forslean has been used for thousands of years in the diet of the population of south India. Very recent clinical studies suggest that it may serve as a potent means of converting fat to lean body mass. Citrin, also known as Garcinia Cambogia has long been used as a safe and effective appetite suppressant. In addition we have added Gymnema Sylvestre and Guggul which are both excellent herbs to help regulate blood sugar levels and reduce fat deposits and cholesterol levels. Bioperen is included in this powerful formula, which enhances the bioavailability of all of the herbs. This is an extremely powerful combination of herbs and is available to you today. Combined with a sensible exercise program and proper diet, Lean Plus will assist you with an effective and safe means of weight loss.

Herbal Actions:

In short, forskolin burns fat through two different pathways: causing the body to burn fat for energy and enhancing thyroid function. Coleus is a member of the mint family, and is native to India and indigenous to its Ayurvedic medicine. Recent studies suggest that use of a standardized root extract from Coleus Forskoli may help to increase lean body mass and optimize body composition. Although traditionally used as a pickle or food spice, Coleus has gained prominence as the only plant source of forskolin.
Forskolin enhances one very important enzyme in the body known as adenylate cyclase, which in turn causes a cascade of hormonal and enzyme reactions resulting in fat being burned for energy. To provide you with an overview of how "A" (forskolin) becomes "Z" (liberated fat), a quick biochemistry lesson is required.

The enzyme adenylate cyclase, when stimulated, enhances the production of cyclic AMP, which in turn activates an enzyme known as protein kinase (a building type of enzyme). Protein kinase, in turn, activates hormone sensitive lipase (which is involved in the breakdown of triglycerides) to stimulate the release of fatty acids from body fat. These liberated fatty acids from body fat can be burned for energy, thus helping you lose fat weight.

Forskolin is also known to stimulate the thyroid (specifically, in stimulating the production of T3). (6) The thyroid, of course, is the master gland for deciding metabolism. If you're unlucky enough to have a sluggish thyroid, you'll have a much harder time shedding fat.
(This explanation of the mechanism by which forskolin functions is quoted from an article by Douglas S. Kalman MS, RD, FACN. To read the article in full please go to Articles)

The compound forskolin is known to enhance adenylate cyclase, an enzyme that splits a high energy molecule of ATP to yield cyclic AMP. Nicknamed in literature as a "second messenger," cyclic AMP facilitates the action of a "primary messenger" or various hormonal and bioactive substances in the body. The role of cyclic AMP is indispensable to many body functions. It causes a chain of biochemical events that paces body metabolism and food induced thermo genesis, and provides mechanisms for controlling body composition and lean body mass.

Metabolism

Forskolin enhances energy production by every cell in the body (due to it elevating the body's cAMP levels).
Forskolin assists the treatment of Hypothyroidism (by stimulating the production and release of Thyroid Hormones).
Forskolin facilitates weight loss in persons afflicted with Obesity (it stimulates the production of cAMP, which in turn regulates the process of lipolysis
Forskolin inhibits the endogenous synthesis of Fatty Acids in Adipocytes.
Forskolin counteracts the decreased response by Adipocytes to Adrenaline (which occurs as a result of the Aging Process).

Clinical Studies

Study design:

ForsLean was tested in an open-field study with a population of six overweight women (BMI greater than 25).

The tested formula was in the form of two-piece, hard shell capsules; each capsule contained 250 mg of the extract.

The overweight, but otherwise healthy women, received the forskolin formula twice daily for eight weeks.

Participants were instructed to take one capsule in the morning and one in the evening, half an hour before a meal.

Each participant was asked to maintain her previous daily physical exercise and eating habits.

In addition, physical activity was monitored based on a questionnaire before and during the trial.

Results:

During the eight week trial, the mean values for body weight and fat content significantly decreased, whereas lean body mass was significantly increased compared to baseline values (Figure 1).

The regimen did not adversely affect the systolic/diastolic blood pressure nor the pulse rate. Indeed, a trend towards lower systolic/diastolic pressure was observed during the course of treatment (Figure 2).

Articles on this product:

ForsLean™

Coleus forskohlii: Fat-Fighting and More

May the Forskolin be with you!

Dosage:
ForsLean has been clinically evaluated at one dose, 250 mg twice daily. This provides 50 mg of forskolin, the primary active compound in ForsLean.

References:

Peer-Reviewed Professional Journals

· Haye, B., et al. Chronic and acute effects of forskolin on isolated thyroid cell metabolism. Mol Cell Endocrinol. 43:41-50, 1990.

· Roger, P. P., et al. Regulation of dog thyroid epithelial cell cycle by forskolin, an adenylate cyclase activator. Exp Cell Res. 172(282-290), 1990.

· Saunier, B., et al. Cyclic AMP regulation of Gs protein. Thyrotropin and forskolin increase the quantity of stimulatory guanine nucleotide-binding proteins in cultured thyroid follicles. J Biol Chem. 265:19942-19946, 1990.

Professional Herbal Newsletters

· Bone, K. The curious case of coleus. Mediherb Professional Newsletter. December 1990.

Forskolin increases the release of thyroid hormones and may therefore be useful for the treatment of (mild) hypothyroidism.

Laypersons’ Publications

· English, J. New research on thermogenesis. Vitamin Research News. April 2000.

Forskolin increases the production and release of thyroid hormones.

· Murray, Michael T. The Healing Power of Herbs (2nd Edition). Prima Publishing, Rocklin, California, USA. 1993:83.

The author advocates the use of forskolin for people with hypothyroidism on the basis of its proven ability to increase the production of thyroid hormones and to stimulate the release of those thyroid hormones.

In-Tele-Health © 2002 (from Hyperhealth Pro CD-ROM)